The palace, located in an area particularly important for the urban development of the city, on the edge of Strada Nuova, in an area of gardens owned by Spinola family and built between 1565 and 1567.

It was built at the behest of Paolo Battista and Nicolò Interiano by Francesco Casella, who worked on the remains of a pre-existing building.

Thanks to its magnificence, the palace was included by Pietro Paolo Rubens in his collection dedicated to the Modern Palaces of Genoa, published in Antwerp, and inscribed in all the lists of the Rolli. The building had several owners. At the end of the seventeenth century it was bought by Grimaldi Pasqua family, who enlarged it upstream using the work of the architect Pietro Pellegrini and renewed some decorative aspects.

This last decorative phase accompanied the rich array of frescoes created by the Calvi family in the sixteenth century, in which particular importance assumes the vault with the Stories of Joshua, located on the main floor.

The last of the property changes hands it to the Pallavicino family, who still hold it today. Particularly interesting is the façade on the square, entirely painted by the brothers Lazzaro and Pantaleo Calvi, as a means of communication and magnification of the figure of one of the two commissioners, Niccolò Interiano, elected in those years Governor of the Republic.