Erected as a compact block on the downstream side of the street from 1558 at the behest of Angelo Giovanni Spinola di Luccoli, banker of the King and Ambassador of the Republic, the palace was constructed by architect Giovanni Ponzello and was soon expanded and immediately enrolled in the “rollo” of 1576, the first “bussolo”.

Past ownership of credit institutions in the early decades of the twentieth century, which still hold the property, the compact block of the building is "broken through" illusively from a wide prospect, which overlooks the Strada Nuova with an important fresh decoration by the lively polychrome, the work of the brothers Lazzaro and Pantaleo Calvi and Semino.

Particularly interesting are the frescoes in the room on the main floor (the so-called Sofonisba Room) overlooking the garden upstream of the building, recently rediscovered and restored: by Lazzaro Tavarone, depict the palace itself in its complete decorative guise as well as some aspects of the garden as it was in its original form.